Aiming at the problem of air purification in medical places, an intelligent IoT air purification system is designed based on human-machine coexistence, efficient sterilization and remote monitoring, including intelligent air purifier and supporting WeChat Mini Program. STM32F103ZET6 is used to design the main control unit of this system, and a variety of sensors are used to collecting the data of indoor air pollutants. The system inhales air with centrifugal fan, filters the particulate matter with HEPA filter and activated charcoal, and sterilize air with plasma and ultraviolet light . It can be controlled by WeChat Mini Program, infrared remote and touch screen. The test results show that the system has stable performance, high air purification efficiency and convenient operation. It can realize man-machine coexistence and remote real-time monitoring and control of air quality in medical place.